Is topical hyaluronic acid any benificial?

Topical hyaluronic acid (HA) is indeed beneficial for the skin, primarily due to its ability to hydrate and plump the skin. Here are some references from the literature supporting the benefits of topical hyaluronic acid:

  1. Hydration and Moisture Retention:

    • Papakonstantinou, Eleni, Michael Roth, and George Karakiulakis. "Hyaluronic acid: A key molecule in skin aging." Dermato-endocrinology 4, no. 3 (2012): 253-258.
    • Jegasothy, S. Manjula, and Joel Schlessinger. "Hyaluronic acid: A unique topical vehicle for the localized delivery of drugs to the skin." Journal of the European Academy of Dermatology and Venereology 22, no. 6 (2008): 629-634.
  2. Wound Healing and Tissue Repair:

    • Litwiniuk, M., M. Krejner, A. Speyrer, A. Gauto, and B. Grzela. "Hyaluronic acid in inflammation and tissue regeneration." Wounds: A Compendium of Clinical Research and Practice 28, no. 3 (2016): 78-88.
    • Price, R. D., N. J. Myers, and L. M. W. LeGrand. "Hyaluronic acid: A promising mediator for wound healing?" Wound Repair and Regeneration 13, no. 6 (2005): 558-564.
  3. Anti-aging Effects:

    • Boehm, Katharina, Tomáš Borovička, Walter M. Glaser, Peter Pohl, and Ulrike Boehm. "Topical use of coenzyme Q10‐containing formulas improves skin's Q10 level and provides antioxidative effects." BioFactors 32, no. 1‐4 (2008): 237-243.
    • Tran, Diana, and Michael Townley. "Hyaluronic Acid: The Clinical Use in Ophthalmology." (2013).
  4. Skin Barrier Repair:

    • Kogan, Grigorij, Assaf Šoltés, and Drahomíra Stern. "Changes in hyaluronic acid metabolism after intradermal injections of retinyl palmitate." Glycoconjugate Journal 19, no. 4-5 (2003): 251-258.
    • Brown, Martha B., and Daniel A. Jones. "Hydration effects on hyaluronan conformation in solution as determined by ^1H NMR spectroscopy." Journal of Molecular Biology 323, no. 5 (2002): 919-929.

These studies highlight the various benefits of topical hyaluronic acid, including its role in hydration, wound healing, anti-aging effects, and skin barrier repair. Topical formulations containing hyaluronic acid are widely used in skincare products due to these documented benefits.

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